A new era is coming for polycystic kidney and liver disease.
Lots of studies being conducted lately, largely single centered but showing promise in the near future on two possible drugs to decrease cyst volume.
We have heard a lot about sirolimus and its effect on the cyst volume and trials showing that it will decrease cyst volume. There is data that if volume is decreased,then the progression to ESRD slows down.
Another drugs is the somatastatin analogues used in neuro endocrine tumors. Three recent trials have shown promise.
Long term data is still needed and more larger studies that are multi centered to validate data.
References:
http://www.ncbi.nlm.nih.gov/pubmed/20431041
http://www.ncbi.nlm.nih.gov/pubmed/19646443
http://www.ncbi.nlm.nih.gov/pubmed/20185596
http://www.ncbi.nlm.nih.gov/pubmed/19917358
http://www.ncbi.nlm.nih.gov/pubmed/20466742
Wednesday, June 9, 2010
IN THE NEWS ---> New treatments for cystic disease
Labels:
CKD and ESRD,
General Nephrology,
In The News
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- IN THE NEWS: Three trials SHOCK the NEPHROLOGY WORLD
- IN THE NEWS:- Angiotensin-receptor blockade and r...
- CONSULT ROUNDS: Hypocomplementemia!
- IN THE NEWS ---> Stem Cells and Kidney Damage
- Answer to Immunology Quiz 2
- Rituximab for induction?
- TOPIC DISCUSSION: Phosphorous containing foods
- Panel Reactive Antibody? how do you calculate?
- Topic Discussion: MYH9 Nephropathies
- Pediatrics Grand rounds continue
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- New blogs of interest
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- CLINICAL CASE 17, ANSWER AND SUMMARY
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- Gurudakshina in Nephrology
- Are you aware of MICA antibodies?
- ISBP Conference Sept 2010
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- Kamal Shah's Blog: An Indian CKD registry now exists
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- IN THE NEWS- Proteinuria and Avastin
- CONSULT ROUNDS: Dialysis Membrane Reactions- Type B
- IN THE NEWS ---> New treatments for cystic disease
- Immunology Quiz 1 Answers
- Rituximab induced lung injury
- TOPIC DISCUSSION: DIABETIC NEPHROPATHY!!
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- IN THE NEWS ---> Detective Nephron strikes again!
- IN THE NEWS --->NephrologyonDemand
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We had a grand rounds from a well regarded expert in ADPKD. You can find some info here:
ReplyDeletehttp://blog.ecu.edu/sites/nephrologyondemand/?p=1827