Lithium can manifest in renal disease in many forms. From Tubular interestitial disease to Nephrogenic DI to hypercalcemia to Glomerular disease.
Hypercalcemia and Lithium directly can lead to a Nephrogenic DI.
What are the reasons lithium causes hypercalcemia?
I thought there was only one reason
But there are three:
1. It directly causes a increase in parathyroid production.
2. It raises the threshold for the calcium sensing of the PTH gland
3. It directly inhibits calcium transport across cells
References
http://www.ncbi.nlm.nih.gov/pubmed/17060004
Image source:
http://www.irishhealth.com/clin/depression/images/lithium.jpg
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