ASN Live Update 2010: VEGF and the podocyte

Podocyte and VEGF
Few take home points from Dr. Susan Quaggin Lecture
1. Local VEGF is important for glomerular development
2.VEGF and VEGF R-2 signal against the flow of urine
3. Modulation of VEGF is important.
4. When you remove VEGF in mice, you get TMA , but when you remove the VEGF-R , no TMA
5. If all VEGF-R2 receptors are removed from entire body endothelial cells, showed TMA in all of the kidney.  The liver  showed endothelial damage and nodular liver as well