TOPIC DISCUSSION: Cryoglobulin Classification Made simple!

Cryoglobulinemia can be damaging to the kidney. Type I,II and III can be associated with certain disorders all of which can be leading to kidney disease.
Type I:- Monoclonal IgG or IgM:- Myeloma, MGUS, Waldenstrom's, CLL, Lymphoma( all of these can have renal involvement)
Type II:- Monoclonal IgM + polyclonal IgG:- most common- Hep C infection, CLL, Idiopathic
Type III:- Polyclonal IgG +IgM:- Lymphoproliferative diseases, some chronic infections, SLE or Rheumatoid Arthritis.

Reference:
Cohen. Eric. Cancer and the Kidney, Second Edition. Oxford Press. 2010.