TOPIC DISCUSSION: LEAD and the KIDNEY

Chronic Lead Nephropathy in a nutshell
1. Minimal Proteinuria
2. Hyperuricemia
3. Benign sediment
4. HTN
5. Interstitial Fibrosis/Tubular Atrophy without cell infiltration
6. Proximal tubules could show acid fast nuclear inclusion bodies- consisting of lead protein binding complex
7. Mitochondrial swelling of renal tubular cells
8. Fanconi Syndrome has been described( usually in acute lead nephropathy)
9. Isolated proximal tubular injury( usually in acute)
10.Osteomalacia
11. Anemia

Ref:
http://www.ncbi.nlm.nih.gov/pubmed/20944550
http://www.ncbi.nlm.nih.gov/pubmed/18220158