CLINICAL CASE 34, ANSWER AND SUMMARY

Which of these genes are linked with diabetic nephropathy?

Angiotensin I Converting Enzyme gene	3 (11%)
Endothelial nitric oxide synthase gene	0 (0%)
Erythropoietin gene	0 (0%)
Gremlin 1 gene	2 (7%)
Protein Kinase C-B1 gene	5 (18%)
Superoxide dismutase 1 gene	2 (7%)
All of the above	15 (55%)

Most of you got this one right. its all of the above. 

A recent literature search and a meta analysis published in Diabetologia

34 replicated genetic variants were identified Of these, 21 remained significantly associated with diabetic nephropathy in a random-effects meta-analysis.  Many were identified and sub divided in different race groups. All the ones mentioned above were important. Please look below at the ref for more data.

http://www.ncbi.nlm.nih.gov/pubmed/21127830