What is renalase? A recently discovered enzyme that might be decreased in CKD. It is thought to metabolize catecholamines.
A recent study showed that knock out mice of renalase had increased plasma catecholamine levels and hypertension. It didn't effect plasma BUN and Crt levels. These mice also ended up having increased ventricular hypertrophy and tolerated ischemia poorly. When given recombinant renalase back:- the rescued the cardiac dysfunction.
These are series of papers coming out on Renalase as an enzyme. It might be an interesting concept to keep in mind as it develops perhaps into a possible agent for treatment of HTN in CKD that might have some catecholamine basis.
Take a look:
http://www.ncbi.nlm.nih.gov/pubmed/21178975
http://www.ncbi.nlm.nih.gov/pubmed/21424526
http://www.ncbi.nlm.nih.gov/pubmed/21099685
http://www.ncbi.nlm.nih.gov/pubmed/19471322
Image source:
www.uscnk.com
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