TOPIC DISCUSSION: Methotrexate in the urine

Methotrexate can cause renal damage is well known but precipitation in the urine and appearance in urine analysis is unique.  Tubular obstruction damage and urine precipitation noted in a recent picture in Kidney International highlights this toxicity.  Check it out below

Ref:
http://www.nature.com/ki/journal/v80/n2/abs/ki201197a.html