Well,
besides few cases reports scattered in the literature, there are two large case
series that highlight this nicely.
In 2001,
Bossini et al described the clinical and morphological features of kidney
involvement in SS. Sixteen patients (27%) had laboratory evidence of
tubular and/or glomerular dysfunction. Renal biopsies from nine patients
showed tubulo‐interstitial nephritis in six and glomerular disease in
three. The three diagnosis were MPGN, mesangiproliferative and membranous.
Patients with renal involvement had a significantly shorter disease duration
compared with patients without renal abnormalities.
A more
recent study in CJASN looked at more number of patients and at least 24
biopsies of SS patients showing mostly tubular interstitial disease but the
glomerular disease was a mixed bag: FSGS, mild mesangial sclerosis, MPGN,
minimal change disease( 1 case), membranous, were the ones reported. The paper
is free access ( look below). Four patients (17%) were diagnosed with
lymphoma during their follow-up. Below is a pie chart from the paper that had
24 cases and the distribution on the biopsy. Overall, not a very common thing
to see in SS, but glomerular disease is likely.
From CJASN 2009
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