Topic Discussion: Glomerular disease in Myeloma

Myeloma cast nephropathy is classically a tubular interstitial disease. Glomerular diseases in myeloma can  be classified as either with organized deposits or amorphous deposits.

1. Organized deposits;- AL amyloidosis ( Usually lambda), Type I and II cyroglobulinemia ( Usually kappa), Immunotactoid GN ( Usually kappa)

2. Amorphous deposits: MIDD ( LCDD, HCDD, LHCDD) - usually kappa if light chain, Proliferative GN with non organized monoclonal Ig deposits ( kappa)

Just another way to think of these patterns in myeloma.