Cryoglobulinemia
associated glomerular disease is most commonly associated with Hepatitis C
infection. What are the other causes of this glomerular disease and hematologic
finding?
That depends on the type of
cryoglobulins. Type I is observed in lymphoproliferative disorders (eg,
multiple myeloma, Waldenström macroglobulinemia) Types II and III are observed
in chronic inflammatory diseases such as chronic liver disease, infections
(chronic HCV infection), and coexistent connective-tissue diseases (SLE,
Sjögren syndrome).
So infections
other than hepatitis C:- Hepatitis B, HIV, Hepatitis A,EBV, CMV, Adenovirus,
Endocarditis, syphilis, Lyme, Q fever,streptococcal
infections, fungal infections and malaria.
Autoimmune
diseases such as
SLE, RA, Sjogren’s. PAN, and HSP are
few others.
Finally,
cancer related causes would be
waldenstrom macroglobulinemia,
leukemia, lymphomas,
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