Secondary Causes of Cryoglobulinemia associated Glomerular Diseases

          Cryoglobulinemia associated glomerular disease is most commonly associated with Hepatitis C infection. What are the other causes of this glomerular disease and hematologic finding?

         That depends on the type of cryoglobulins. Type I is observed in lymphoproliferative disorders (eg, multiple myeloma, Waldenström macroglobulinemia) Types II and III are observed in chronic inflammatory diseases such as chronic liver disease, infections (chronic HCV infection), and coexistent connective-tissue diseases (SLE, Sjögren syndrome).

So infections other than hepatitis C:- Hepatitis B, HIV, Hepatitis A,EBV, CMV, Adenovirus, Endocarditis, syphilis, Lyme, Q fever,streptococcal infections, fungal infections and malaria.

Autoimmune diseases such as SLE, RA, Sjogren’s. PAN, and HSP are few others.

Finally, cancer related causes would be waldenstrom macroglobulinemia, leukemia, lymphomas,