CONSULT ROUNDS: TINU

Tubular interstitial disease and Uvietis (TINU) 
Some interesting facts:

1. First described in 1975
2. Usually seen in young females more than males
3. Usually uvietis occurs 2-3 months prior to the renal disease but can be as late as a year after renal disease.
4. Elevated ESR and b2 microglobulin levels might be the only lab clue
5. Sarcoidosis and Sjorgren's syndrome have to be ruled out
6. There is some indication that this might fit into the big category of IgG4 related diseases
7. Not uncommon to see proximal tubular dysfunction.
8. Treatment is steroids for 3-6 months.