Topic Discussion: Hormonal levels with various RAAS blockade medications

Class of RAAS agent	Renin level	Plasma renin activity	Ang II level	Aldosterone level
Renin inhibitor	Elevated	Low	Low	Low
ACEI inhibitor*	Elevated	Elevated	Low	Low
ARB*	Elevated	Elevated	Elevated	Low
Aldo receptor blocker	Elevated	Elevated	Elevated	Elevated

* after being on ACEI/ARB for long periods, due to aldosterone breakthrough, aldosterone levels could be high in some cases.